Saturday, November 15, 2025

I’m on 6 medications that cause significant weight gain

I’m 5’4”. I used to be 130 lbs, but after falling chronically ill, I gained 50 lbs in 3 months. I kept gaining over the years, and I just reached 200 lbs. I’m not happy with this.

My initial 3-month weight gain was due to being put on corticosteroids and Zyprexa for severe status migraine. I have massive purple stretch marks all over my body. I look like a zebra.

I’m currently on 7 medications that can cause significant weight gain. I’m on the maximum dose of amitriptyline, which is a VERY potent appetite stimulant, as well as gabapentin, trazodone, propranolol, guanfacine, oral contraceptive, and baclofen. I can’t change any of these meds. I’m eating constantly. I’m in intensive psychotherapy for binge-eating disorder, but every time we increase a dose of my meds, all my progress goes down the toilet. I can’t tolerate any of the weight loss meds including stimulants and GLP-1’s. I work out 6 times per week (4 strength training days and 2 cardio days), yet I keep gaining weight. I have a nutritionist.

At this point, I’m just praying for bariatric surgery. Let me know if anybody has any tips. I‘m starting to struggle with thoughts such as “I’m too fat to be seen in public,” so I really need help dealing with the psychological side effects of gaining this much weight.

submitted by /u/Unlikely-Yam1427
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