Hi there! Im a cico gal and i understand that weight loss is basically energy in vs energy out and that’s how you lose weight and will continue to lose weight as long as the ins are less than the outs. Simple physics & chemistry right.. What i don’t understand is how biological factors can play a role in “slowing” that process. The famous example is how i keep seeing people say that their metabolism adjusts or adapt to the deficit which in turn stops their weight loss? starvation mode? how is that possible. The role of hormones also confuses me bc why do docs say it’s harder to lose weight with PCOS or hypothyroidism? feel free to explain it as scientifically as you can since im a molecular scientist/ geneticist myself but i simply can’t wrap my head around it. If i had to guess, i’d say starvation mode doesn’t actually exist or else the universe would collapse lol. And for hormonal/biological issues maybe its the case of lowering the TDEE/BMR of a person? like its still cico but the body’s natural “calories out” part is less than the average person? Im currently also studying how genetics play a factor in this and somehow the genetics part makes sense to me but the hormonal/metabolism part just doesn’t. I’d really love to know
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